# Revolution for Dogs and Cats: Complete Guide to Selamectin Treatment
Overview
Revolution is a revolutionary monthly topical antiparasitic medication that has transformed parasite prevention in dogs and cats. This prescription-only medication contains selamectin, a powerful avermectin compound that provides broad-spectrum protection against multiple parasites with a single application. Revolution offers pet owners and veterinarians a convenient, effective solution for preventing heartworm disease, controlling flea infestations, and treating various other parasitic conditions.
Unlike traditional parasite prevention methods that often require multiple products, Revolution simplifies parasite control by addressing several threats simultaneously. The medication is applied directly to the skin between the shoulder blades, where it's absorbed systemically to provide month-long protection. This innovative approach has made Revolution a cornerstone of modern veterinary preventive medicine.
Always consult your veterinarian before starting Revolution treatment to ensure it's appropriate for your pet's specific health needs and parasite risk profile.
How Revolution Works
Revolution's active ingredient, selamectin, belongs to the avermectin class of antiparasitic compounds. Once applied topically, selamectin is rapidly absorbed through the skin and distributed throughout the body via the bloodstream. The medication works by interfering with the nervous system of parasites, specifically targeting glutamate-gated chloride channels that are essential for parasite survival.
When parasites encounter selamectin in the pet's system, the compound binds to these chloride channels, causing an influx of chloride ions that leads to hyperpolarization of nerve cells. This mechanism results in paralysis and death of the parasites. Importantly, mammals have different chloride channels that are not significantly affected by selamectin, which explains the medication's safety profile in dogs and cats.
The systemic distribution of selamectin means it can eliminate parasites that come into contact with the pet's blood, skin, or other tissues. This comprehensive coverage makes Revolution particularly effective against parasites with different life stages and feeding behaviors.
Uses and Indications
Revolution is FDA-approved for multiple parasitic conditions in dogs and cats:
For Dogs:
- Heartworm prevention: Prevents heartworm disease caused by Dirofilaria immitis
- Flea control: Kills adult fleas and prevents flea eggs from hatching
- Tick control: Effective against American dog ticks
- Sarcoptic mange: Treats scabies caused by Sarcoptes scabiei
- Ear mites: Eliminates Otodectes cynotis infestations
For Cats:
- Heartworm prevention: Prevents heartworm disease
- Flea control: Comprehensive flea life cycle interruption
- Ear mites: Treatment of Otodectes cynotis
- Roundworms: Treatment of Toxocara cati infections
- Hookworms: Effective against Ancylostoma tubaeforme
Revolution is particularly valuable in areas with high parasite prevalence and for pets with multiple parasite risks. The medication's broad spectrum makes it ideal for comprehensive parasite prevention programs.
Dosage Guidelines
Revolution dosing is based on body weight and species, with specific formulations available for different weight ranges. The medication is packaged in single-dose tubes color-coded by weight category.
Dogs:
- Small dogs (5-10 lbs): 30mg selamectin (0.25ml)
- Medium dogs (10.1-20 lbs): 60mg selamectin (0.5ml)
- Large dogs (20.1-40 lbs): 120mg selamectin (1.0ml)
- Extra-large dogs (40.1-85 lbs): 240mg selamectin (2.0ml)
- Giant dogs (85.1-130 lbs): 360mg selamectin (3.0ml)
Cats:
- Cats and kittens (2.6-7.5 lbs): 15mg selamectin (0.25ml)
- Large cats (7.6-15 lbs): 45mg selamectin (0.75ml)
For pets between weight ranges, use the next higher dose. Dogs over 130 pounds should receive appropriate combination doses as directed by a veterinarian. Puppies and kittens can begin Revolution treatment as early as 6 weeks of age.
Administration Instructions
Proper application is crucial for Revolution's effectiveness:
1. Preparation: Remove the tube from packaging and hold upright. Press cap down firmly and twist counterclockwise to break the seal.
2. Application site: Part the hair between the shoulder blades at the base of the neck, in front of the shoulder blades, to expose the skin.
3. Application: Place the tube tip directly on the skin and squeeze firmly to empty the entire contents in one spot. Avoid getting the medication in eyes or mouth.
4. Post-application: Do not touch the application site until dry. Keep pets separated if multiple animals are treated to prevent grooming of wet application sites.
5. Timing: Apply monthly, year-round for optimal protection. Mark calendar dates to ensure consistent dosing intervals.
Important: Do not bathe pets or allow swimming for 2 hours after application to ensure proper absorption.
Side Effects and Adverse Reactions
Revolution is generally well-tolerated, but like all medications, it can cause side effects in some pets.
Common Side Effects:
- Temporary hair loss or discoloration at application site
- Mild skin irritation or redness
- Temporary greasy appearance of fur
- Slight lethargy on application day
Less Common Side Effects:
- Digestive upset (vomiting, diarrhea)
- Decreased appetite
- Excessive salivation (if pet licks application site)
- Temporary behavioral changes
Serious Adverse Reactions (Seek Immediate Veterinary Care):
- Severe allergic reactions (facial swelling, difficulty breathing)
- Persistent vomiting or diarrhea
- Neurological symptoms (tremors, seizures, ataxia)
- Severe skin reactions or persistent irritation
Most side effects are mild and resolve within 24-48 hours. However, any concerning symptoms warrant veterinary consultation.
Precautions and Warnings
Several important precautions must be observed when using Revolution:
General Precautions:
- Prescription only: Revolution requires veterinary prescription and oversight
- Species-specific: Use only dog formulations on dogs and cat formulations on cats
- Age restrictions: Not recommended for puppies or kittens under 6 weeks old
- Heartworm testing: Dogs should be tested for existing heartworm infection before starting prevention
Special Populations:
- Pregnant/nursing animals: Use only under veterinary supervision
- Sick or debilitated pets: May require dosage adjustments or alternative treatments
- Collie breeds: Generally safe, but monitor closely due to potential MDR1 gene sensitivity
Human Safety:
- Wash hands thoroughly after application
- Avoid contact with application site until dry
- Keep away from children during application
- Do not smoke, eat, or drink during application
Drug Interactions
Revolution has relatively few significant drug interactions, but several considerations apply:
- Other avermectins: Avoid concurrent use with ivermectin, milbemycin, or moxidectin without veterinary guidance
- Spinosad products: May increase selamectin absorption; monitor for side effects
- Ketoconazole: May affect selamectin metabolism
- Vaccines: Generally compatible, but inform veterinarian of all medications
Always provide your veterinarian with a complete list of all medications, supplements, and treatments your pet receives.
Storage and Handling
Proper storage ensures Revolution's effectiveness and safety:
- Store at room temperature (59-77°F/15-25°C)
- Keep in original packaging until use
- Protect from light and moisture
- Do not freeze
- Keep out of reach of children and pets
- Dispose of empty tubes according to local regulations
- Do not use past expiration date
Frequently Asked Questions
Can Revolution be used with other flea treatments?
Generally, Revolution should not be combined with other flea treatments without veterinary approval. Using multiple flea products simultaneously can increase the risk of side effects and may not provide additional benefits. Always consult your veterinarian before combining parasite control products.
What should I do if my pet gets wet after Revolution application?
If your pet gets wet within 2 hours of application, the effectiveness may be reduced. Contact your veterinarian to determine if reapplication is necessary. After 2 hours, normal bathing and swimming activities can resume without affecting the medication's efficacy.
How quickly does Revolution start working against fleas?
Revolution begins killing fleas within 12 hours of application, with maximum effectiveness reached within 24-36 hours. You may still see some fleas for several days as the medication eliminates the existing population and prevents new infestations.
Is Revolution safe for pregnant or nursing pets?
Revolution has been used safely in pregnant and nursing animals, but should only be administered under veterinary supervision. Your veterinarian will assess the benefits versus risks based on your pet's specific situation and parasite exposure risk.
Can I split a larger dose for a smaller pet?
No, never split Revolution doses between pets. Each tube is formulated for specific weight ranges and splitting doses can result in inadequate protection or overdosing. Always use the appropriate size for each individual pet's weight range.