Overview
Alfaxalone is a neuroactive steroid anesthetic widely used in veterinary medicine for inducing anesthesia in pets, particularly dogs and cats. It offers a rapid onset and short duration of action, making it a preferred choice for short procedures.
How It Works
Alfaxalone works by enhancing the activity of gamma-aminobutyric acid (GABA) receptors in the brain, leading to sedation and loss of consciousness. This mechanism results in smooth induction and recovery from anesthesia.
Uses & Indications
Alfaxalone is primarily used for:
- Induction of anesthesia
- Maintenance of anesthesia
- Sedation for short, minor procedures
Dosage Guidelines
Dogs
- Small Dogs: 1-2 mg/kg IV
- Medium Dogs: 2-3 mg/kg IV
- Large Dogs: 3-4 mg/kg IV
Cats
- Standard: 5 mg/kg IV
Administration
Alfaxalone is administered via injection and is typically given intravenously for rapid effect.
Side Effects
Common
- Hypotension
- Respiratory depression
Rare
- Excitement during recovery
Severe
- Severe respiratory depression requiring veterinary attention
Precautions & Warnings
- Use with caution in animals with cardiovascular disease.
- Monitor respiratory and cardiovascular function during anesthesia.
Drug Interactions
- May interact with other CNS depressants.
- Use caution when combined with other anesthetics.
Storage
Store below 25°C (77°F) and protect from light. Do not freeze.
FAQ
Is Alfaxalone safe for puppies?
Alfaxalone can be used in puppies under veterinary guidance.
Can Alfaxalone be used for long procedures?
It is typically used for short procedures but can be maintained with repeat doses as needed.
What to do if my pet shows severe side effects?
Contact your veterinarian immediately if severe side effects occur.
How long does it take for Alfaxalone to work?
Alfaxalone typically works within minutes when administered intravenously.
Is Alfaxalone a controlled substance?
Alfaxalone is not a controlled substance but requires a prescription.